Effects of Shentong Zhuyu Decoction on PI3K/Akt Pathway Bad, Caspase-9, GSK-3β Expression of Human Nucleus Pulposus Cells Click Copy

Effects of Shentong Zhuyu Decoction on PI3K/Akt Pathway Bad, Caspase-9, GSK-3β Expression of Human Nucleus Pulposus Cells

References:

[1] DINO S, JARO K, FLORENCE M, et al. A population-based study of juvenile disc degeneration and its association with overweight and obesity, low back pain, and diminished functional status[J]. Journal of Bone & Joint Surgery-American Volume,2011,93(7):662-670.

[2] CHIWARIDZO M, NAIDOO N. Prevalence and associated characteristics of recurrent non-specific low back pain in Zimbabwean adolescents:a cross-sectional study[J]. BMC Musculoskeletal Disorders,2014,15(1):1-10.

[3] DENG X, CHEN S, ZHENG D, et al. Icariin Prevents H2O2-induced apoptosis via the PI3K/Akt pathway in rat nucleus pulposus intervertebral disc cells[J]. Evidence-Based Complementray and Alternative Medicine,2017,24(4):254-261.

[4] LIU B, CONG W, CHEN P, et al. RACKI induces chemotherapy resistance in esophageal carcinoma by upregulating the PI3K/AKT pathway and Bcl-2 expression[J]. Oncotargets & Therapy,2018, 4(11):211-220.

[5] OBI S, YAMAMOTO K, ANDO J, et al. Differentiation of circulating endothelial progenitor cells induced by shear stress[C]// International Symposium on Micro-nanomechatronics & Human Science,2012:4-7.

[6] YANG J, ZOU Y, JIANG D. Honokiol suppresses proliferation and induces apoptosis via regulation of the miR-21/PTEN/PI3K/AKT signaling pathway in human osteosarcoma cells[J]. International Journal of Molecular Medicine,2018,41(4):1845-1854.

[7] MANOS S, JIN L, PHILLIP P, et al. ISSLS Prize winner:Mechanical influences in progressive intervertebral disc degeneration[J]. Spine,2014,39(17):1365-1372.

[8] COSTA R L B, HAN H S, GTADISHAR W J. Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review[J]. Breast Cancer Research & Treatment,2018,169(6):1-10.

[9] COMELIA N W, ANTJE M, CHRISTINA R, et al. Interactions of environmental conditions and mechanical loads have influence on matrix turnover by nucleus pulposus cells[J]. Journal of Orthopaedic Research,2011,30(1):112-121.

[10] HIROAKI H, TAKASHI Y, KENICHIRO K, et al. A rat tail temporary static compression model reproduces different stages of intervertebral disc degeneration with decreased notochordal cell phenotype[J]. Journal of Orthopaedic Research,2014,32(3):455-463.

[11] ZHANG C C, ZHOU J S, HU J G, et al. Effects of IGF-1 on IL-1β-induced apoptosis in rabbit nucleus pulposus cells in vitro[J]. Molecular Medicine Reports,2013,7(2):440-441.

[12] MOENCH R, GRIMMIG T, KANNEN V, et al. Exclusive inhibition of PI3K/Akt/mTOR signaling is not sufficient to prevent PDGF- mediated effects on glycolysis and proliferation in colorectal cancer[J]. Oncotarget,2016,7(42):68749-68767.

[13] JIANG L, YUAN F, YIN X, et al. Responses and adaptations of intervertebral disc cells to microenvironmental stress:a possible central role of autophagy in the adaptive mechanism[J]. Connective Tissue Research,2014,55(5/6):311.

[14] ZHAO Y, PANG W, YANG N, et al. MicroRNA-511 inhibits malignant behaviors of breast cancer by directly targeting SOX9 and regulating the PI3K/Akt pathway[J]. International Journal of Oncology,2018,53(6):2715-2726.

[15] 许早荣,郑爱红.身痛逐瘀汤加减治疗慢性腰痛的体会[J].中国民间疗法,2018,26(4):30-31.

[16] 王宾,武师伟,刘长信,等.孙呈祥教授治疗筋伤病用药经验[J].现代中医临床,2016,23(5):46-48

[17] 李东山.身痛逐瘀汤加减治疗腰椎间盘突出症的临床价值分析[J].中国医药指南,2013,11(33):206-207.

[18] 吴刚忠.加味身痛逐瘀汤治疗腰椎间盘突出症18例[J].湖南中医杂志,2014,30(9):88.

[19] 叶志坚,邵大清,方韬.中西医结合治疗腰椎间盘突出症疼痛的临床研究[J].中华中医药学刊,2015,33(5):1249-1251.

Memo

基金项目:国家自然科学基金(81603638);中央高校基本科研业务费专项资金(2018-JYB-XJQ010);北京中医药大学基本科研业务费项目(2017-JYB-JS-085、2019-JYB-JS-042);北京中医大学东直门医院青苗人才项目(DZMYS-201702)