Effects of Lianxia Ningxin Prescription on Left Ventricular Remodeling and JAK1/STAT3 Signal Pathway in Rats with Myocardial Infarction Click Copy

Effects of Lianxia Ningxin Prescription on Left Ventricular Remodeling and JAK1/STAT3 Signal Pathway in Rats with Myocardial Infarction

References:

[1] BENJAMIN E J, VIRANI S S, CALLAWAY C W, et al. Heart disease and dtroke dtatistics-2018 update:A report from the American heart association[J]. Circulation,2018,137(12):e67-e492.

[2] 罗慧玲.急性心肌梗死后24h内发生心衰及1个月后心衰转归的相关因素分析[D].长春:吉林大学,2018.

[3] 高玉桥,苏丹,张汉辉.中药干预JAK/STAT信号通路的研究进展[J].时珍国医国药,2018,29(9):2236-2240.

[4] EL-ADAWI H, DENG L, TRAMONTANO A, et al. The functional role of the JAK-STAT pathway in post-infarction remodeling[J]. Cardiovasc Res,2003,57(1):129-138.

[5] 于晓晗,王一非,戴方圆,等.以连夏宁心颗粒为代表的清热化痰法治疗冠心病心绞痛的临床研究[J].世界中西医结合杂志,2019,14(5):707-711.

[6] 吴爱明.稳心颗粒干预MI大鼠miR-1/miR-133表达改善缝隙连接和心室重构防治室颤研究[D].北京:北京中医药大学,2018.

[7] 杨涛涛,肖颖,奚赛飞,等.大鼠心肌梗死模型构建和评价方法的改良[J].中国比较医学杂志,2014,24(2):46-51.

[8] HAQUE Z K, WANG D Z. How cardiomyocytes sense pathophysiological stresses for cardiac remodeling[J]. Cell Mol Life Sci,2017, 74(6):983-1000.

[9] 郝腾,李平.从痰热论治冠心病体会[J].国医论坛,2016,31(3):58- 59.

[10] 朱国东.连夏宁心方有效组分及临床应用研究[D].北京:北京中医药大学,2017.

[11] 于晓晗.连夏宁心颗粒对冠心病患者的影响及部分相关机制的研究[D].北京:北京中医药大学,2019.

[12] BOOZ G W, DAY J N, BAKER K M. Interplay between the cardiac renin angiotensin system and JAK-STAT signaling:role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failure[J]. J Mol Cell Cardiol,2002,34(11):1443-1453.

[13] ZHANG S, LIU X, GOLDSTEIN S, et al. Role of the JAK/STAT signaling pathway in the pathogenesis of acute myocardial infarction in rats and its effect on NF-kappaB expression[J]. Mol Med Rep,2013,7(1):93-98.

[14] CHENEVARD R, HURLIMANN D, BECHIR M, et al. Selective COX-2 inhibition improves endothelial function in coronary artery disease[J]. Circulation,2003,107(3):405-409.

[15] 夏勇,张勇,李东野,等.塞来昔布对心肌梗死后心肌细胞凋亡的影响[J].中国病理生理杂志,2007,23(1):49-52.

[16] ZHANG C, WANG F, ZHANG Y, et al. Celecoxib prevents pressure overload-induced cardiac hypertrophy and dysfunction by inhibiting inflammation, apoptosis and oxidative stress[J]. J Cell Mol Med,2016,20(1):116-127.

[17] 梁子敬,曾量波,叶政,等.特异性COX-2抑制剂对压力负荷性心肌肥厚大鼠左心室重构的影响[J].中华急诊医学杂志,2005,14(6):479- 481.

[18] YANG Y, YANG K, HAO T, et al. Prediction of molecular mechanisms for LianXia NingXin formula:A network pharmacology study[J]. Front Physiol,2018,9:489.

[19] 杨阳.利用网络药理学方法探讨连夏宁心方治疗冠心病痰热证药理学机制的临床与基础研究[D].北京:北京中医药大学,2019.

[20] ZHEN Y, WU Q, DING Y, et al. Exogenous hydrogen sulfide promotes hepatocellular carcinoma cell growth by activating the STAT3-COX-2 signaling pathway[J]. Oncol Lett,2018,15(5):6562- 6570.

[21] XIONG H, DU W, SUN T T, et al. A positive feedback loop between STAT3 and cyclooxygenase-2 gene may contribute to Helicobacter pylori-associated human gastric tumorigenesis[J]. Int J Cancer, 2014,134(9):2030-2040.

Memo

基金项目:国家自然科学基金(81960852);山东省自然科学基金(ZR2017BH063)