Mechanism of Huoxue Yiqi Decoction in Promoting Angiogenesis After Myocardial Infarction Based on Network Pharmacology Click Copy

Mechanism of Huoxue Yiqi Decoction in Promoting Angiogenesis After Myocardial Infarction Based on Network Pharmacology

《中国中医药信息杂志》[ISSN:1005-5304/CN:11-3519/R] Volume: 27卷 Issue: 2020年12期 Page: 76-82 Research Field: 中医药信息学 Publishing date: 2020-12-01
Title:
Mechanism of Huoxue Yiqi Decoction in Promoting Angiogenesis After Myocardial Infarction Based on Network Pharmacology
Author(s):
WU Dandan;  GUO Qianqian;  GAO Yijie;  WANG Manman;  JIA Dongdong;  YANG Rui;  ZHANG Dongmei;  ZHU Ke
Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China
Keywords:
Huoxue Yiqi Decoction;  network pharmacology;  myocardial infarction;  angiogenesis
PACS:
R259.422.2；R285
DOI:
10.19879/j.cnki.1005-5304.201911494
Abstract:
Objective To discuss the basis of active components of Huoxue Yiqi Decoction in promoting angiogenesis after myocardial infarction based on network pharmacology; To predict its possible mechanism. Methods Chinese materia medica in Huoxue Yiqi decoction including Astragali Radix, Codonipsis Radix, Salviae Miltiorrhizae et Rhizoma, Chuanxiong Rhizoma , Paeoniae Radix Rubra and Carthami Flos were searched in TCMSP, active components were screened by OB ≥ 30% and DL ≥ 0.18, and corresponding targets with effective components were obtained. The targets of angiogenesis after myocardial infarction were retrieved from OMIM and GeneCards databases. The intersection between the target of Huoxue Yiqi Decoction and the targets of angiogenesis after myocardial infarction was input into String database to obtain the PPI relationship and core targets according to the close degree of protein interaction. The core target-drug composition interaction network was visualized by using the software Cytoscape 3.7.0, and the network was analyzed by topology. The targets were analyzed by GO and KEGG pathway enrichment using DAVID database. Results Totally 148 active components of Huoxue Yiqi Decoction and 275 targets were obtained. At the same time, 418 disease targets were obtained. There were 78 intersection targets. The PPI results showed that STAT3, JUN and AKT1 were closely related to other targets. GO biological function analysis and KEGG pathway enrichment of targets were found to involve 447 biological function items and 101 signaling pathways. Conclusion Huoxue Yiqi Decoction regulates the treatment of angiogenesis after myocardial infarction through multi-component, multi-target, multi-pathway.

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Memo

基金项目：国家自然科学基金面上项目（81273694、81973780）；北京中医药大学基本科研业务费项目（2019-BUCMXJKT017）