[1]王德才,李同德,徐晓燕.独活香豆素组分对戊巴比妥钠及巴比妥钠催眠作用的影响[J].中国中医药信息杂志,2007,14(11):31-32.
WANG De-cai,LI Tong-de,XU Xiao-yan.Influence of the Coumarins from Radix Angelicae Pubescentis on the Hypnotic Effects of Pentobarbital Sodium and Barbital Sodium in Mice[J].zhongguo zhongyiyao xinxi zazhi,2007,14(11):31-32.
点击复制WANG De-cai,LI Tong-de,XU Xiao-yan.Influence of the Coumarins from Radix Angelicae Pubescentis on the Hypnotic Effects of Pentobarbital Sodium and Barbital Sodium in Mice[J].zhongguo zhongyiyao xinxi zazhi,2007,14(11):31-32.
独活香豆素组分对戊巴比妥钠及巴比妥钠催眠作用的影响
《中国中医药信息杂志》[ISSN:1005-5304/CN:11-3519/R] 卷:
14卷 期数:
2007年11期 页码:
31-32
栏目:
实验研究 出版日期:
2007-11-15
- Title:
- Influence of the Coumarins from Radix Angelicae Pubescentis on the Hypnotic Effects of Pentobarbital Sodium and Barbital Sodium in Mice
- 文章编号:
- 1005-5304(2007)11-0031-02
- Keywords:
- coumarins from Radix Angelicae Pubescentis; pentobarbital sodium; barbital sodium; hypnotic effect; mice
- 分类号:
- R285.5
- 文献标志码:
- A
- 摘要:
- 目的 观察独活香豆素组分(TCA)对戊巴比妥钠及巴比妥钠催眠作用的影响。方法 将小鼠随机分为溶媒(5%吐温-80,20 mL/kg)、氯霉素(25 mg/kg)及TCA(50、100 mg/kg)组,等容灌胃给药1 h后,再腹腔注射戊巴比妥钠40 mg/kg或巴比妥钠200 mg/kg,观察催眠潜伏期和催眠时间。结果 氯霉素和高、低剂量的TCA使戊巴比妥钠的催眠时间延长249.8%、171.1%和78.7%,均P<0.01；对巴比妥钠的催眠作用无明显影响。结论 TCA对小鼠肝微粒体细胞色素P450具有一定的抑制作用。
- Abstract:
- Objective To observe the influence of the coumarins from Radix Angelicae pubescentis (TCA) on the hypnotic effects of pentobarbital sodium and barbital sodium. Methods Mice were randomly divided into solvent (5% Tween-80, 20 mL/kg), chloromycetin (25 mg/kg) and TCA (50, 100 mg/kg) groups, which were administered orally with equivalent volume. One hour later, all the animals were given pentobarbital sodium (40 mg/kg, ip) or barbital sodium (200 mg/kg, ip), and then the latent period and duration of hypnosis were observed. Results Hypnotic duration of pentobarbital sodium was prolonged by 249.8%, 171.1% and 78.7% in chloromycetin and two TCA groups respectively (P<0.01), and yet hypnotic effect of barbital sodium was hardly influenced. Conclusion TCA is likely to inhibit liver microsomal cytochrome P450 activity in mice.
参考文献/References:
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