[1]杨梦琳,周小青,伍大华,等.何首乌-石菖蒲药对治疗阿尔茨海默病网络药理学研究及实验验证[J].中国中医药信息杂志,2021,28(8):36-41.[doi:10.19879/j.cnki.1005-5304.202005395]
 YANG Menglin,ZHOU Xiaoqing,WU Dahua,et al.Network Pharmacology Research and Experimental Calidation of Polygonimultiflori Radix- Acori Tatarinowii Rhizoma in Treating Alzheimer Disease[J].zhongguo zhongyiyao xinxi zazhi,2021,28(8):36-41.[doi:10.19879/j.cnki.1005-5304.202005395]
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何首乌-石菖蒲药对治疗阿尔茨海默病网络药理学研究及实验验证

参考文献/References:

[1] ANAND R, GILL K D, MAHDI A A. Therapeutics of Alzheimer’s disease:Past, present and future[J]. Neuropharmacology,2014, 76(Pt A):27-50.

[2] 荣蓉,曲连悦,孙珊珊,等.阿尔茨海默病的药物治疗研究现状[J].中国临床药理学杂志,2019,35(5):489-492.

[3] 任抒婷,王蕾,吴煜然,等.治疗阿尔茨海默症的中药有效成分研究进展[J].淮海工学院学报(自然科学版),2018,27(3):28-33.

[4] BERK C, PAUL G, SABBAGH M. Investigational drugs in Alzheimer ’s disease:current progress[J]. Expert Opin Investig Drugs,2014, 23(6):837-846.

[5] 朱杰,张钊,董一筱,等.阿尔茨海默病及其治疗药物研究进展[J].中国药理学通报,2018,34(12):1629-1634.

[6] YUAN D P, QIU X F, WANG P, et al. Deficiency of kidney and febility of marrow, blockage of brain vollateral:basic patho-genesis of Alzheimer’s disease[J]. Chin J Tradit Chin Med Pharm,2008,23(8):732-734.

[7] 任红微,魏静,高秀梅,等.何首乌及其主要化学成分[J].中草药, 2019,50(4):951-956.

[8] 龚彦胜,张亚囡,黄伟,等.与功效、毒性相关的何首乌化学成分研究进展[J].中国药物警戒,2012,9(8):472-475.

[9] 陈永灿.强记益智话菖蒲[J].浙江中医杂志,2011,46(12):905.

[10] 杨小金,邓艾平,王奕,等.石菖蒲化学成分及药理作用研究进展[J].内蒙古中医药,2017,36(19):132.

[11] 杜晨旭,杨帆,杨承芝.补肾化痰祛瘀复方治疗阿尔茨海默病用药规律研究[J].现代中医药,2017,37(4):85-91.

[12] 兴桂华,吴淑琴,官杰.养寿丹对AD大鼠学习记忆能力及NGF、TrkA蛋白表达的影响[J].中国老年学杂志,2014,34(6):1572-1575.

[13] YANG Y, LIU J P, FANG J Y, et al. Effect and safety of Huannao Yicong Formula (还脑益聪方) in patients with mild-to-moderate Alzheimer’s disease:A randomized, double-blinded, Donepezil- controlled trial[J]. Chinese Journal of Integrative Medicine, 2019,25(8):574-581.

[14] 张运辉,伍大华,袁春云,等.二苯乙烯苷和三七总皂苷配伍对Aβ25-35致PC12细胞损伤影响的研究[J].湖南中医药大学学报,2015,35(9):20-22.

[15] 刘宁,杨晓颖,黄健,等.二苯乙烯苷对APP/PS1双转基因小鼠海马区病理形态学及脑BACE1表达的影响[J].右江民族医学院学报,2016, 38(6):559-562.

[16] 张旭.二苯乙烯苷对α-突触核蛋白过表达和聚集的影响及其作用机制[D].北京:首都医科大学,2017.

[17] GENG Y, LI C, LIU J, et al. Beta-asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection rats[J]. Biol Pharm Bull,2010,33(5):836- 843.

[18] 江湧,方永奇,邹衍衍.β-细辛醚对痴呆小鼠学习记忆能力及SOD、GSH-Px和MDA水平的影响[J].中国老年学杂志,2007,27(12):1126- 1127.

[19] 侯德仁,陈坤,王艳,等.丁苯酞治疗血管性痴呆的疗效和作用机制[J].南方医科大学学报,2009,29(3):574-575.

[20] MCDONALD D R, BAMBERGER M E, COMBS C K, et al. β-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes[J]. Journal of Neuroscience:the Official Journal of the Society for Neuroscience, 1998,18(12):4451-4460.

[21] KALTSCHMIDT B, UHEREK M, VOLK B, et al. Transcription factor NF-kappa B is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease[J]. Proceedings of the National Academy of Sciences,1997,94(6):2642-2647.

[22] DE SOUZA C T, ARAUJO E P, BORDIN S, et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus[J]. Endocrinology,2005, 146(10):4192-4199.

[23] BIJLI K M, FAZAL F, RAHMAN A. Regulation of Rela/p65 and endothelial cell inflammation by proline-rich tyrosine kinase 2[J]. American Journal of Respiratory Cell & Molecular Biology,2012, 47(5):660-668.

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备注/Memo

基金项目:国家自然科学基金(81373702、81874462)

更新日期/Last Update:

2021-07-20