LIU Jing,ZHU Qi.The Improvement of Immunity in Colorectal Caner Patients Receiving Jianpi Herbs Combine Chemotherapy：A Systematic Review[J].zhongguo zhongyiyao xinxi zazhi,2009,16(12):104-106.
健脾中药联合化疗改善大肠癌患者免疫功能的系统评价
- Title:
- The Improvement of Immunity in Colorectal Caner Patients Receiving Jianpi Herbs Combine Chemotherapy：A Systematic Review
- 文章编号:
- 1005-5304(2009)12-0104-03
- Keywords:
- Jianpi; chemotherapy; colorectal cancer; immunity; systematic review; randomized controlled trial
- 分类号:
- R2-05
- 文献标志码:
- A
- 摘要:
- 目的 评价健脾中药联合化疗对大肠癌患者免疫功能的改善作用。方法 通过计算机检索中国生物医学文献光盘数据库(CBMdisc)、中国期刊全文数据库(CJFD)、万方数据医药信息系统(Wangfang Data),收集有关健脾中药联合化疗与单用化疗比较的随机对照研究,并采用Cochrane协作网提供的RevMan4.2.10软件进行Meta分析。 结果 纳入血清CD3、CD4/CD8、NK水平的研究分别为5、7、5个。所有入选研究方法学质量评价均为C级。与单用化疗比较,健脾中药联合化疗可显著提高大肠癌患者血清CD3(SMD＝0.53,95%CI：0.33～0.73,P＜0.000 1)、CD4/CD8(SMD＝0.50,95%CI：0.33～0.67,P＜0.000 1)和NK(SMD＝1.29,95%CI：0.95～1.62,P＜0.000 1)水平。结论 目前有关健脾中药联合化疗治疗大肠癌的随机对照研究在方法学应用方面仍有差距。本评价显示健脾中药联合化疗可能改善大肠癌患者的免疫功能,但结论有待高质量的随机对照临床研究进一步证实。
- Abstract:
- Objective To assess the improvement of immunity in colorectal cacer patients receiving Jianpi herbs combine chemotherapy. Methods The randomized controlled trials (RCTs) comparing Jianpi herbs combine chemotherapy with routine chemotherapy were searched through CBMdisc, CJFD, Wangfang Data by computerized retrieval. RevMan4.2.10, provided by Cochrane library, was used to perform Meta analysis. Results RCTs enrolled to assess the serum CD3, CD4/CD8, NK level were 5, 7, 5, respectively. The methodology quality of all enrolled RCTs was level C. To compare with routine chemotherapy, Jianpi herbs combine chemotherapy significantly increased the serum CD3 (SMD＝0.53, 95%CI：0.33～0.73, P＜0.000 1), CD4/CD8 (SMD＝0.50, 95%CI：0.33～0.67, P＜0.000 1) and NK (SMD＝1.29, 95%CI：0.95～1.62, P＜0.000 1) level. Conclusion The methodological quality of the RCTs using Jianpi herbs combine chemotherapy on treating colorectal cancer should be improved. Based on this systematic review, Jianpi herbs combine chemotherapy may improve the immunity of colorectal cancer patients. Well-designed RCTs are needed in the future.
参考文献/References:
[1] 李连弟,鲁凤珠,张思维,等.中国恶性肿瘤死亡率20年变化趋势和近期预测分析[J].中华肿瘤杂志,1997,19(1)：3－9. [2] 郑 树,蔡善荣.中国大肠癌的病因学及人群防治研究[J].中华肿瘤杂志,2004,26(1)：1－3. [3] Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials：Is blinding necessary[J]. Control Clin Trials,1996,17(1)：1－12. [4] Moher D, Pham B, Jones A, et al. Does quality of reports of randomized trials affect estimates of intervention efficacy in Meta-analysis[J]. Lancet,1998,352(128)：609－613. [5] 李华山,唐宗江,张志勇,等.肠癌康复汤对大肠癌患者术后免疫功能的影响[J].大肠肛门病外科杂志,1999,5(2)：21－24. [6] 潘敏求,潘 博,黎月恒.益气调腑汤配合化疗治疗大肠癌43例临床观察[J].湖南中医药导报,2003,9(11)：12－14. [7] 刘 静,王维平,周奕阳,等.健脾活血中药配合化疗治疗对大肠癌术后患者免疫和血液流变学的影响[J].江苏中医药,2005,26(7)：13－14. [8] 杨 彦,刘碧清,杜秋霞.肠复康胶囊治疗中晚期大肠癌55例临床研究[J].江苏中医药,2005,26(1)：18－19. [9] 蒋益兰,潘敏求,蔡 美.健脾消癌饮配合化疗拮抗大肠癌术后复发转移62例总结[J].湖南中医杂志,2007,23(1)：1－3. [10] 张 青,梁松岳,赵文硕,等.益气活血中药联合化疗治疗晚期大肠癌的临床研究[J].中国中医药信息杂志,2006,13(10)：17－18. [11] 梁松岳.肠复方合并化疗治疗大肠癌40例总结[J].湖南中医杂志, 2005,21(3)：33－34. [12] 赵文硕,张 青,于 洁,等.加味升血汤配合化疗治疗中晚期大肠癌的临床研究[J].国际中医中药杂志,2006,28(9)：306－308. [13] 刘 静,张 军,朱 琦.中医药治疗大肠癌辨证用药分析[J].辽宁中医杂志,2006,33(9)：1166－1167. [14] 刘 静,朱 琦,张 军.中医药治疗大肠癌临床研究文献的质量分析[J].中国中医基础医学杂志,2006,12(5)：387－388.
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