GUO Xiao-yan,ZHANG Hui-yong,LU Zhen-hui,et al.Effect of Chuanxiong Pingchuan Mixture on Inflammatory Factors of Patients with Branchial Asthma in Acute Exacerbation[J].zhongguo zhongyiyao xinxi zazhi,2011,18(8):13-15.[doi:10.3969/j.issn.1005-5304.2011.08.006]
川芎平喘合剂治疗支气管哮喘急性发作期患者临床疗效及对炎性因子水平的影响
- Title:
- Effect of Chuanxiong Pingchuan Mixture on Inflammatory Factors of Patients with Branchial Asthma in Acute Exacerbation
- 文章编号:
- 1005-5304(2011)08-0013-03
- 分类号:
- R259.622.5
- 文献标志码:
- A
- 摘要:
- 目的 探讨川芎平喘合剂对支气管哮喘急性发作期患者血清炎性因子水平的影响。方法 将66例哮喘急性发作期患者随机分为2组。对照组给予西医常规治疗,治疗组在常规治疗基础上给予川芎平喘合剂,每次20 mL,每日3次。疗程均为14 d。观察2组临床疗效及治疗前后肺功能的变化,采用酶联免疫吸附法(ELISA)检测血清肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)水平。结果 治疗组临床疗效优于对照组,但无明显差异。经治疗,治疗组咳嗽、喘息、胸闷、气短症状积分明显低于对照组(P＜0.05),血清TNF-α、IL-6水平均较对照组明显下降(P＜0.05),1秒用力呼气容积(FEV1)、呼气峰值流速(PEF)改善均优于对照组(P＜0.05)。结论 川芎平喘合剂具有缓解哮喘急性发作期患者临床症状、改善肺功能的作用,其机制可能与降低体内TNF-α、IL-6过度表达,抑制炎性反应有关。
- Abstract:
- Objective To evaluate the effect of Chuanxiong Pingchuan Mixture on inflammatory factors of patients with branchial asthma in acute exacerbation. Methods Sixty-six patients with branchial asthma attack were divided into the therapy group (36 cases) and the control group (28 cases). The therapy group received 20 mL Chuanxiong Pingchuan Mixture, twice a day, on the basis of conventional therapy, while the control group received conventional therapy only. The treatment course of both groups was 14 days. The clinical therapeutic effects of both groups were observed, and the lung function of all patients were measured before and after treatment. The serum level of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) were measured by enzymelabeled immunosorbent assay (ELISA). Results The clinical effect of therapy group was higher than that of control group, with no significant difference. The symptom scores of the cough, shortness of breath, chest tightness and wheezing of therapy group were lower than that of control group (P＜0.05). The serum level of TNF-α and IL-6 in therapy group was lower than that in control group (P＜0.05). The improvement of FEV1 and PEF in therapy group was better than that in control group (P＜0.05). Conclusions Chuanxiong Pingchuan Mixture may relieve the symptoms and improve the lung function of the patients with branchial asthma in acute exacerbation. The mechanism may be related with decreasing the serum level of TNF-α and IL-6, and inhibiting the inflammatory response.
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备注/Memo
基金项目：上海市中医优势专科(专病)建设项目(2008)
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