ZHANG Ping,WU Huan,LIU Quan,et al.Clinical Efficacy and Related Influencing Factors of Jianpi Huatan Decoction Plus Zhongwan Moxibustion in Patients with Mild to Moderate Stable COPD[J].zhongguo zhongyiyao xinxi zazhi,2014,21(3):29-32,108.[doi:10.3969/j.issn.1005-5304.2014.03.009]
健脾化痰方配合温灸中脘治疗轻中度稳定期慢性阻塞性肺疾病临床疗效及相关影响因素分析
- Title:
- Clinical Efficacy and Related Influencing Factors of Jianpi Huatan Decoction Plus Zhongwan Moxibustion in Patients with Mild to Moderate Stable COPD
- 文章编号:
- 1005-5304(2014)03-0029-04
- Keywords:
- Jianpi Huatan Decoction; moxibustion; Zhongwan (RN12); stable COPD; quality of life; regression analysis
- 分类号:
- R259.639
- 文献标志码:
- A
- 摘要:
- 目的 观察健脾化痰方配合温灸中脘治疗肺脾气虚型轻、中度稳定期慢性阻塞性肺疾病(COPD)患者的临床疗效,并分析其相关影响因素。方法 采用前瞻性随机对照临床试验,将符合标准的140例轻、中度稳定期COPD患者随机分为治疗组(健脾化痰方配合温灸中脘＋西医基础治疗)和对照组(西医基础治疗),每组70例。治疗12周,随访12周。观察2组患者治疗前后临床症状及生存质量评分变化,并通过多分类logistic回归分析,分析可能对疗效产生影响的主要因素。结果 治疗后2组主要临床症状较治疗前均显著改善(P＜0.01),治疗组显著优于对照组(P＜0.01)。治疗组治疗后生存质量较治疗前及对照组均显著提高(P＜0.01),对照组治疗后生存质量无明显改善(P＞0.05)。多分类logistic回归分析显示,治疗方式及病情程度对临床疗效有显著影响(P＜0.05,P＜0.01)。结论 健脾化痰方配合温灸中脘治疗肺脾气虚型轻、中度稳定期COPD具有显著疗效,并可改善生存质量；治疗方式及病情轻重程度为影响临床疗效的主要因素。
- Abstract:
- Objective To observe the clinical efficacy of Jianpi Huatan Decoction plus Zhongwan (RN12) moxibustion on patients of mild to moderate stable chronic obstructive pulmonary disease (COPD) with syndrome of qi deficiency of lung and spleen, and analyze the related influencing factors. Methods With prospective randomized clinical trial, 140 cases of mild to moderate stable COPD were randomized into two groups (70 cases for each group). Treatment group was treated by Jianpi Huatan Decoction plus Zhongwan moxibustion based on western medicine, and control group was only treated by western medicine. Both groups were treated for 12 weeks and followed up for 12 weeks. Scores of clinical symptoms and quality of life questionnaire were examined, and multiple logistic regression analysis was used to find possible impacting factors on the effect. Results Symptoms were significantly alleviated after treatment (P＜0.01) in both groups. The clinical effects and quality of life in treatment group were significantly improved than the control group (P＜0.01). There were no significant changes in life quality of control group (P＞0.05). Multiple logistic regression analysis showed that different therapies and severity of COPD were the major influencing factors of clinical effect (P＜0.05, P＜0.01). Conclusion Jianpi Huatan Decoction plus Zhongwan moxibustion had significant therapeutic effect on mild to moderate stable COPD patients with syndrome of qi deficiency of lung and spleen by alleviating symptoms and improving quality of life. Treatment style and severity of COPD are the main influencing factors.
参考文献/References:
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备注/Memo
基金项目：上海市卫生局科研课题计划(2008222)；上海市教育委员会重点学科-中医脾胃病学(J50305)
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