基于国家专利的中药复方治疗心力衰竭用药规律研究

Title:

Study on Medication Rules of Compound TCM with National Patents for Treatment of Heart Failure

文章编号:

1005-5304(2018)08-0098-04

作者:

郭建波¹; 2; 何庆勇¹; 王阶¹; 丁宇坤¹; 2; 王辉¹; 2; 代爽¹; 2; 覃堃¹; 2; 但文超¹; 2

1.中国中医科学院广安门医院，北京 100053；2.北京中医药大学，北京 100029

Author(s):

GUO Jian-bo¹; 2;  HE Qing-yong¹;  WANG Jie¹;  DING Yu-kun¹; 2;  WANG Hui¹; 2;  DAI Shuang¹; 2;  QIN Kun¹; 2;  DAN Wen-chao¹; 2

1. Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China; 2. Beijing University of Chinese Medicine, Beijing 100029, China

关键词:

心力衰竭; 专利; 证候; 配伍规律; 中药复方

Keywords:

heart failure;  patents;  syndrome;  compatibility rules;  compound TCM

分类号:

R2-05；R259.416.1

DOI:

10.3969/j.issn.1005-5304.2018.08.022

文献标志码:

A

摘要:

目的 通过分析心力衰竭中药复方专利的用药及配伍规律，为中药新药研发提供参考。方法 计算机检索国家知识产权局中国专利公布公告网站（http://epub.sipo.gov.cn/）中治疗心力衰竭的中药复方专利数据，采用中医传承辅助平台（V2.5）频次统计、关联规则、复杂网络、熵聚类等方法进行分析。结果 纳入2003年9月－2017年11月治疗心力衰竭的中药复方专利120项，涉及药物383味，最常见的主治证候为气虚血瘀水停证（41次，34.17%）；常用药物为黄芪（62次，51.67%），常用药对为丹参-黄芪（31次，25.83%），常用角药为黄芪-茯苓-葶苈子（16次，13.33%）；置信度较高的关联规则有“丹参，当归→黄芪”（0.933）、“党参，白术→黄芪”（0.900）、“人参，葶苈子→茯苓”（0.889）；核心药物为黄芪、人参、丹参等；新处方有“桂枝、五加皮、大枣、枳实、天麻”“白术、桂枝、大枣、当归、赤芍”等。结论 临床研发心力衰竭中药新药时，应针对其常见主治证候，活用益气、温阳、活血、化瘀、利水、化痰、养阴药物，以提高临床功效。

Abstract:

Objective To provide references for research and development of new TCM by analyzing the medication and compatibility rules of compound TCM patents for treatment of heart failure. Methods All compound TCM patents related to the treatment of heart failure were extracted from the national patent database ( http://epub.sipo.gov.cn/). Frequency statistics, association rules, complex network, entropy clustering method of TCM Auxiliary Inheritance Platform (V2.5) were used to analyze the data . Results Totally 120 compound TCM patents from September 2003 to November 2017 for the treatment of heart failure were included, involving 383 kinds of Chinese materia medica, and the most common syndrome was qi-deficiency blood-stasis water-stop syndrome (41 times, accounting for 34.17%). The most common Chinese materia medica was Astragali Radix (62 times, accounting for 51.67%). The most common medical combination was Salviae Miltiorrhizae Radix et Rhizoma-Astragali Radix (31 times, accounting for 25.83%). The most common triple combination was Astragali Radix-Poria-Descurainiae Semen Lepidii Semen (16 times, accounting for 13.33%). Confidence-based association rules were “Salviae Miltiorrhizae Radix et Rhizoma, Angelicae Sinensis Radix→Astragali Radix” (0.933), “Codonopsis Radix, Atractylodix Macrocephalae Rhizoma→Astragali Radix” (0.900), “Ginseng Radix et Rhizoma, Descurainiae Semen Lepidii Semen→Poria” (0.889) . The core Chinese materia medica were Astragali Radix, Ginseng Radix et Rhizoma, Salviae Miltiorrhizae Radix et Rhizoma, etc . The new prescriptions were “Cinnamomi Ramulus, Acanthopanacis Cortex, Jujubae Fructus, Aurantii Fructus Immaturus, and Gastrodiae Rhizoma”, “Atractylodix Macrocephalae Rhizoma, Cinnamomi Ramulus, Jujubae Fructus, Angelicae Sinensis Radix, and Paeoniae Radix Rubra”, etc. Conclusion Clinical research and development of new TCM for the treatment of heart failure should give priority to main syndromes, flexibly using medicines for tonifying qi, warming yang, activating blood circulation, dissipating blood stasis, inducing diuresis, reducing phlegm, and nourishing yin, to promote clinical efficacy.