[1]宫彩霞,王志强.基于足细胞损伤的中药治疗糖尿病肾病分子机制研究进展[J].中国中医药信息杂志,2019,26(12):136-140.[doi:10.3969/j.issn.1005-5304.2019.12.031]
 GONG Caixia,WANG Zhiqiang.Research Progress in Molecular Mechanism of Diabetic Nephropathy Treated by TCM Based on Podocyte Injury[J].zhongguo zhongyiyao xinxi zazhi,2019,26(12):136-140.[doi:10.3969/j.issn.1005-5304.2019.12.031]
点击复制

基于足细胞损伤的中药治疗糖尿病肾病分子机制研究进展

参考文献/References:

[1] American Diabetes Association. Standards of medical care in diabetes-2018[J]. Diabetes Care,2018,41(Suppl 1):S7-S153.

[2] LIN J S, SUSZTAK K. Podocytes:the weakest link in diabetic kidney disease?[J]. Curr Diab Rep,2016,16(5):45.

[3] LOEFFLER I, WOLF G. Epithelial-to-mesenchymal transition in diabetic nephropathy:fact or fiction?[J]. Cells,2015,4(4):631-652.

[4] MATHEW S, CHEN X, POZZI A, et al. Integrins in renal development[J]. Pediatric Nephrology,2012,27(6):891-900.

[5] JIM B, GHANTA M, QIPO A, et al. Dysregulated nephrin in diabetic nephropathy of type 2 diabetes:a cross sectional study[J]. PLoS One,2012,7(5):e36041.

[6] CHEN J, CHEN Y, LUO Y, et al. Astragaloside Ⅳ ameliorates diabetic nephropathy involving protection of podocytes in streptozotocin induced diabetic rats[J]. Eur J Pharmacol,2014, 736:86-94.

[7] GUI D, WEI L, JIAN G, et al. Notoginsenoside R1 ameliorates podocyte adhesion under diabetic condition through α3β1 integrin upregulation in vitro and in vivo[J]. Cell Physiol Biochem,2014,34(6):1849-1862.

[8] 王旭焘,潘定一,郭玮,等.阿魏酸对糖尿病大鼠肾脏足细胞nephrin、podocin蛋白表达的影响[J].中国应用生理学杂志,2017,33(6):564- 567.

[9] DAI H, LIU Q, LIU B. Research progress on mechanism of podocyte depletion in diabetic nephropathy[J]. J Diabetes Res,2017,20172615286.

[10] LEE S H, MOON S J, PAENG J, et al. Podocyte hypertrophy precedes apoptosis under experimental diabetic conditions[J]. Apoptosis, 2015,20(8):1056-1071.

[11] MUKHI D, NISHAD R, MENON R K, et al. Novel actions of growth hormone in podocytes:implications for diabetic nephropathy[J]. Front Med (Lausanne),2017,4:102.

[12] 郭维文,廖水玉,李佑生.小檗碱对高糖诱导的小鼠足细胞凋亡的影响[J].上海中医药杂志,2017,51(11):68-71.

[13] SUN L N, LIU X C, CHEN X J, et al. Curcumin attenuates high glucose-induced podocyte apoptosis by regulating functional connections between caveolin-1 phosphorylation and ROS[J]. Acta Pharmacol Sin,2016,37(5):645-655.

[14] 李艳,秦洁,张姬欣,等.高糖、高同型半胱氨酸致足细胞内质网应激时白藜芦醇对CHOP通路的影响[J].中华临床医师杂志(电子版),2014, 8(3):481-484.

[15] GUO H, CAO A, CHU S, et al. Astragaloside Ⅳattenuates podocyte apoptosis mediated by endoplasmic reticulum stress through upregulating sarco/endoplasmic reticulum Ca2+-ATPase 2 expression in diabetic nephropathy[J]. Front Pharmacol,2016,7:500.

[16] RANI V, DEEP G, SINGH R K, et al. Oxidative stress and metabolic disorders:Pathogenesis and therapeutic strategies[J]. Life Sci, 2016,148(1):183-193.

[17] BHATTI A B, USMAN M. Drug targets for oxidative podocyte injury in diabetic nephropathy[J]. Cureus,2015,7(12):e393.

[18] 陈宇宁,吴晨光,钱珂,等.积雪草酸对糖尿病大鼠肾脏足细胞损伤的影响[J].中国新药与临床杂志,2014,33(10):741-746.

[19] 李雪玲,林小靖,朱青青,等.葛根素保护高糖环境下足细胞损伤的氧化应激机制[J].中国中西医结合肾病杂志,2018,19(1):45-48.

[20] 肖文珍,桂定坤,陈廷芳,等.黄芪甲苷的抗氧化应激作用对体外高糖刺激足细胞的保护作用[J].中国中西医结合肾病杂志,2013,14(5):384-387.

[21] ZHAO L, WANG X, SUN L, et al. Critical role of serum response factor in podocyte epithelial-mesenchymal transition of diabetic nephropathy[J]. Diab Vasc Dis Res,2016,13(1):81-92.

[22] 陈廷芳,郭永平,桂定坤,等.黄芪甲苷干预高糖诱导的足细胞转分化的体外研究[J].中国中西医结合肾病杂志,2017,18(6):482-485.

[23] 赵小丽,徐建伟,刘丽秋.雷公藤甲素对高糖刺激足细胞转分化的影响[J].山东医药,2014,54(6):14-17.

[24] 赵敬,王颖超,赵宗江,等.糖肾平通过TGF-β1-Smad2/3-ILK信号通路干预高糖+LPS诱导足细胞上皮间质转分化的分子机制研究[J].中国中西医结合肾病杂志,2014,15(5):392-396.

[25] MAEZAWA Y, TAKEMOTO M, YOKOTE K. Cell biology of diabetic nephropathy:Roles of endothelial cells, tubulointerstitial cells and podocytes[J]. J Diabetes Investig,2015,6(1):3-15.

[26] BOSE M, ALMAS S, PRABHAKAR S. Wnt signaling and podocyte dysfunction in diabetic nephropathy[J]. J Investig Med,2017, 65(8):1093-1101.

[27] LIU B L, CHEN Y P, CHENG H , et al. The protective effects of curcumin on obesity-related glomerulopathy are associated with inhibition of Wnt/β-catenin signaling activation in podocytes[J]. Evid Based Complement Alternat Med,2015,2015:827472.

[28] 石格,吴薇,万毅刚,等.低剂量雷公藤甲素抑制Wnt3α/β-catenin信号通路活性改善高剂量D-葡萄糖诱导的足细胞转分化[J].中国中药杂志,2018,43(1):139-146.

[29] 吴影懿.大黄酸对db/db小鼠肾损伤的保护作用及其对足细胞Wnt/β-catenin信号通路的影响[D].南京:南京医科大学,2015.

[30] 孙胜君.榛花消肾胶囊干预实验性糖尿病大鼠足细胞转分化Wnt/β- catenin通路的研究[D].长春:长春中医药大学,2013.

[31] HARE S H, HARVEY A J. mTOR function and therapeutic targeting in breast cancer[J]. Am J Cancer Res,2017,7(3):383-404.

[32] LIEBERHAL W, LEVINE J S. Mammalian target of rapamycin and the kidney. Ⅱ. Pathophysiology and therapeutic implications[J]. Am J Physiol Renal Physiol,2012,303(2):F180-F191.

[33] HUANG G, LV J, LI T, et al. Notoginsenoside R1 ameliorates podocyte injury in rats with diabetic nephropathy by activating the PI3K/Akt signaling pathway[J]. Int J Mol Med,2016,38(4):1179-1189.

[34] HUANG G, ZOU B, LV J, et al. Notoginsenoside R1 attenuates glucose-induced podocyte injury via the inhibition of apoptosis and the activation of autophagy through the PI3K/Akt/mTOR signaling pathway[J]. Int J Mol Med,2017,39(3):559-568.

[35] MAO N, TAN R Z, WANG S Q, et al. Ginsenoside Rg1 inhibits angiotensin Ⅱ-induced podocyte autophagy via AMPK/mTOR/PI3K pathway[J]. Cell Biol Int,2016,40(8):917-925.

[36] 毛志敏.雷公藤多苷调控mTORC1信号通路活性改善糖尿病肾病足细胞损伤的作用和机制[D].南京:南京中医药大学,2016.

[37] PREVIS R A, COLEMAN R L, HARRIS A L, et al. Molecular pathwaystranslational and therapeutic implications of the Notch signaling pathway incancer[J]. Clin Cancer Res,2015,21(5):955-961.

[38] GAO F, YAO M, SHI Y, et al. Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways[J]. J Cell Biochem,2013,114(5):1029-1038.

[39] 尚懿纯,曹式丽,杨洪涛,等.肾苏Ⅱ方对局灶节段性肾小球硬化大鼠Notch-PI3K/PKB通路及足细胞EMT的影响[J].中华中医药杂志,2016, 31(12):5271-5276.

[40] 尚懿纯,曹式丽,杨洪涛,等.肾苏Ⅱ方对局灶节段性肾小球硬化大鼠Notch-P53通路及足细胞凋亡的影响[J].中国中西医结合肾病杂志, 2017,37(8):973-978.

[41] 姜甫昇.榛花消肾安胶囊干预实验性糖尿病大鼠足细胞转分化notch通路研究[D].长春:长春中医药大学,2017.

[42] KIM M Y, LIM J H, YOUN H H, et al. Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1α axis in db/db mice[J]. Diabetologia,2013,56(1):204-217.

[43] 陈霞,曹爱丽,彭文.黄芪汤通过AMPK-Camkkβ(LKB1)信号通路对足细胞的保护作用研究[J].吉林中医药,2017,37(9):945-948.

相似文献/References:

[1]廖利平,林晓生,易炳学,等.关于中药方剂编码的研究[J].中国中医药信息杂志,2011,18(1):34.[doi:10.3969/j.issn.1005-5304.2011.01.013]
 LIAO Li-ping,LIN Xiao-sheng,YI Bing-xue,et al.Study on Chinese Herbal Medicine Prescription Coding[J].zhongguo zhongyiyao xinxi zazhi,2011,18(12):34.[doi:10.3969/j.issn.1005-5304.2011.01.013]
[2]董宇,王阶,杨庆,等.CYP450酶与中药代谢相互作用关系研究概况[J].中国中医药信息杂志,2011,18(1):100.[doi:10.3969/j.issn.1005-5304.2011.01.052]
 [J].zhongguo zhongyiyao xinxi zazhi,2011,18(12):100.[doi:10.3969/j.issn.1005-5304.2011.01.052]
[3]康旭亮,吕茂平,李洪梅.抗流行性感冒的中药发明专利状况分析[J].中国中医药信息杂志,2012,19(3):1.[doi:10.3969/j.issn.1005-5304.2012.03.001]
 [J].zhongguo zhongyiyao xinxi zazhi,2012,19(12):1.[doi:10.3969/j.issn.1005-5304.2012.03.001]
[4]王仲易,李敏.针药结合治疗下元虚寒型小儿遗尿症疗效观察[J].中国中医药信息杂志,2014,21(3):92.[doi:10.3969/j.issn.1005-5304.2014.03.029]
 [J].zhongguo zhongyiyao xinxi zazhi,2014,21(12):92.[doi:10.3969/j.issn.1005-5304.2014.03.029]
[5]高欣,康立源,高秀梅.脑缺血后神经细胞凋亡通路及中药干预[J].中国中医药信息杂志,2007,14(7):96.
 [J].zhongguo zhongyiyao xinxi zazhi,2007,14(12):96.
[6]张萍.中西药配伍的药理分析[J].中国中医药信息杂志,2007,14(7):104.
 [J].zhongguo zhongyiyao xinxi zazhi,2007,14(12):104.
[7]田 茸,陈 丽,杨延婷,等.单味中药抗癫痫效应的规律分析及其Logistic回归模型[J].中国中医药信息杂志,2010,17(11):97.
 [J].zhongguo zhongyiyao xinxi zazhi,2010,17(12):97.
[8]刘 盈,黄璐琦,边宝林,等.中药新药研发医、研、产合作创新网络构建探讨[J].中国中医药信息杂志,2010,17(12):7.[doi:10.3969/j.issn.1005-5304.2010.12.004]
 [J].zhongguo zhongyiyao xinxi zazhi,2010,17(12):7.[doi:10.3969/j.issn.1005-5304.2010.12.004]
[9]刘起华,文谨,王菲,等.中药穴位给药应用研究概述[J].中国中医药信息杂志,2010,17(2):104.
 [J].zhongguo zhongyiyao xinxi zazhi,2010,17(12):104.
[10]傅骞,胡素敏,周鹏,等.尾部悬吊3周及中药干预对模拟失重大鼠全身骨密度的影响[J].中国中医药信息杂志,2010,17(1):28.
 FU Qian,HU Su-min,ZHOU Peng,et al.Effect of Hindlimb Unloaded 3 Weeks and Chinese Herbal Prescriptions on Systemic Bone Mineral Density in Simulated Weightlessness Rats[J].zhongguo zhongyiyao xinxi zazhi,2010,17(12):28.
[11]张舒媛,李博,王东超,等.中药治疗糖尿病肾病研究进展[J].中国中医药信息杂志,2015,22(12):121.[doi:10.3969/j.issn.1005-5304.2015.12.038]
 ZHANG Shu-yuan,LI Bo,WANG Dong-chao,et al.Research Progress on Traditional Chinese Medicine in Treatment of Diabetic Nephropathy[J].zhongguo zhongyiyao xinxi zazhi,2015,22(12):121.[doi:10.3969/j.issn.1005-5304.2015.12.038]

备注/Memo

基金项目:上海市自然科学基金(17ZR1430600);上海市教育委员会科研创新计划项目(2017-01-07-00-10-E00064);上海市浦东新区卫计委联合攻关项目(PW2017D-4)(收稿日期:2018-07-30)

更新日期/Last Update:

2019-11-18