[1]卢冬雪,刘峰,严晶,等.基于系统生物学的中医证候研究进展[J].中国中医药信息杂志,2020,27(6):131-135.[doi:10.3969/j.issn.1005-5304.201904078]
 LU Dongxue,LIU Feng,YAN Jing,et al.Research Progress in TCM Syndromes Based on Systems Biology[J].zhongguo zhongyiyao xinxi zazhi,2020,27(6):131-135.[doi:10.3969/j.issn.1005-5304.201904078]
点击复制

基于系统生物学的中医证候研究进展

参考文献/References:

[1] 张敏.传统文化对中医“证”理论形成的影响[J].河南中医,2011, 31(8):839-840.

[2] WANG X, ZHANG A, SUN H. Future perspectives of Chinese medical formulae:chinmedomics as an effector[J]. OMICS,2012,16(7/8):414-421.

[3] 胡学军,蔡光先,刘柏炎,等.蛋白质组学在中医“证”实质研究中的应用[J].中华中医药杂志,2008,22(2):87-91.

[4] 宋剑南.论中医证候基础研究的模式和方法[J].中国中医基础医学杂志,2007,13(2):81-83.

[5] 王永炎,张启明,张志斌.证候要素及其靶位的提取[J].山东中医药大学学报,2006,30(1):6-7.

[6] KITANO H. Foundations of systems biology[M]. London:MIT Press Camgbridge,MA,2001:10-11.

[7] 胡志峰,肖诚,何燕,等.系统生物学将会促进中医药学的发展[J].上海中医药杂志,2007,41(2):1-4.

[8] 李晓红,梁媛,李晶晶,等.系统生物学与中医证本质研究[J].中国中医基础医学杂志,2011,17(2):211-212.

[9] 沈自尹.中西医结合肾本质研究回顾[J].中国中西医结合杂志, 2012,32(3):304-306.

[10] 危北海,陈小野.脾气虚证实质的初步揭示[J].中国中西医结合脾胃杂志,1999,7(4):193-195.

[11] 蒋跃绒,殷惠军,刘颖,等.血瘀证基础研究的若干思考[J].中国中医基础医学杂志,2005,11(8):561-563.

[12] HOOD L, HEATH J R, PHELPS M E, et al. Systems biology and new technologies enable predictive and preventative medicine[J]. Science,2004,306(5696):640-643.

[13] AUFFRAY C, CHEN Z ,HOOD L. Systems medicine:The future of medical genomics and healthcare[J]. Genome Med,2009,1(1):2.

[14] DAI J, SUN S, CAO J, et al. Similar connotation in chronic hepatitis B and nonalcoholic Fatty liver patients with dampness- heat syndrome[J]. Evid Based Complement Alternat Med,2013,2013:793820.

[15] LU C, XIAO C, CHEN G, et al. Cold and heat pattern of rheumatoid arthritis in traditional Chinese medicine: Distinct molecular signatures indentified by microarray expression profiles in CD4-positive T cell[J]. Rheumatol Int,2012,32(1):61-68.

[16] 刘雅荣,李晶洁,吕书勤,等.基于核磁共振的脾虚湿盛证肝癌患者血浆代谢组学研究[J].世界科学技术-中医药现代化,2016,18(2):296- 301.

[17] ZHAO H,CHEN J,SHI Q,et al. Metabolomics-based study of clinical and animal plasma samples in coronary heart disease with blood stasis syndrome[J]. Evid Based Complement Alternat Med,2012, 2012:638723.

[18] 谢世平,左刚.运用系统生物学研究中医证候的思考仁[J].世界中医药,2011,6(5):369-372.

[19] JACQUIER A. The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs[J]. Nat Rev Genet, 2009,10(12):833.

[20] JIANGT T, WEI L L, SHI L Y, et al. Microarray expression profile analysis of mRNAs and long non-coding RNAs in pulmonary tuberculosis with different traditional Chinese medicine syndromes[J]. Bmc Complem Altern Med,2016,16(1):472.

[21] 王阶,滕菲,刘咏梅,等.血塞通对冠心病不稳定型心绞痛血瘀证患者microRNA的干预作用[J].中国实验方剂学杂志,2017,23(19):11-16.

[22] 廖江铨.冠心病血瘀证相关lncRNA-miRNA-mRNA调控网络研究[D].北京:北京中医药大学,2017.

[23] 陈德轩,蔡红蝶,宿树兰,等.中医病证相符的大鼠疮疡模型的建立及其血浆、尿液代谢组学研究[J].中医药学报,2019,47(1):17-22.

[24] 马琪.基于代谢组学和网络药理学的白头翁汤治疗湿热泄泻的作用机制研究[D].兰州:甘肃农业大学,2018.

[25] 王佳婕,曹云,李中峰,等.基于核磁共振氢谱的慢性复发型溃疡性结肠炎中医虚、实证候血浆代谢组学研究[J].北京中医药大学学报,2018, 41(9):787-792.

[26] ZHAO L, WAN L, QIU X, et al. A metabonomics profilings study on phlegm syndrome and blood-stasis syndrome in coronary heart disease patients using liquid chromatography/guadrupole time- of-flight mass spectrometry[J]. Evid Based Complement Alternat Med,2014,2014:385102.

[27] 罗朵生,李坤平,朴胜华,等.高脂血症大鼠病程进展的尿液代谢组学的研究[J].广东药学院学报,2016,32(2):224-227.

[28] XIE G X, WANG Y X, WANG X N, et al. Profiling of serum bile acids in a healthy Chinese population using UPLC-MS/MS[J]. J Proteome Res,2015,14(2):850-859.

[29] 张少强,鞠静,朱明丹,等.慢性心力衰竭不同证型的代谢组学研究[J].时珍国医国药,2019,30(2):507-509.

[30] 西旺,闫起,王燕,等.基于中医方证代谢组学分析四物汤对自然衰老小鼠的干预作用[J].中国实验方剂学杂志,2019,25(12):9-14.

[31] 王磊琼,段新科,董宝刚.慢性乙型病毒性肝炎中医虚证的蛋白质组学规律初探[J].光明中医,2012,27(3):458-459.

[32] 欧阳秋芳,郭鹊晖,连艳平,等.基于真武汤药物反证的心肾综合征阳虚水泛证血清蛋白组学研究[J].时珍国医国药,2016,27(10):2555- 2557.

[33] 王端,贺莉,张婕,等.应用蛋白质组学技术筛选抽动障碍患儿不同中医证型血清相关蛋白[J].中国妇幼健康研究,2018,29(2):149-153.

[34] 李依洁.基于脑-肠互动温肾健脾法干预腹泻型肠易激综合征的蛋白组学研究[D].北京:北京中医药大学,2017.

[35] 赵静.基于蛋白组学技术对2型糖尿病大鼠病证模型特点及中药复方干预作用的研究[D].北京:北京中医药大学,2016.

[36] 刘雄,曾平,秦刚,等.系统性红斑狼疮合并激素性股骨头坏死中医证型的血清差异蛋白质组学研究[J].中华中医药学刊,2018,36(11):2662-2666.

[37] 汪梅姣.基于粪便上清代谢组学及基因组学探讨脾虚型痛风的生物学特征[D].杭州:浙江中医药大学,2013.

[38] 汪洋.基于粪便上清代谢组学及基因组学探讨类风湿关节炎脾虚证的生物学特征[D].杭州:浙江中医药大学,2013.

[39] 孙丙银,赵宝祥,韦标方.激素性股骨头坏死中医证候与CYP1A2基因多态性的关联研究[J].南京中医药大学学报,2015,31(3):210-213

[40] 翁莉,杜鹃,何文婷,等.原发性肝癌肝肾阴虚证患者外周血单个核细胞的特征性差异基因[J].中西医结合学报,2012,10(4):406-415.

相似文献/References:

[1]王宁群,李宗信,黄小波,等.老年脑梗死患者睡眠、情绪障碍及中医证候特征研究[J].中国中医药信息杂志,2010,17(12):21.[doi:10.3969/j.issn.1005-5304.2010.12.009]
 WANG Ning-qun,LI Zong-xin,HUANG Xiao-bo,et al.Characteristics of Sleep Disturbance, Emotional Disorder and Syndrome Types of Elder Cerebral Infarction Patients[J].zhongguo zhongyiyao xinxi zazhi,2010,17(6):21.[doi:10.3969/j.issn.1005-5304.2010.12.009]
[2]戴霞,邹艳君,部帅,等.老年高血压病证候分布规律的临床回顾性研究[J].中国中医药信息杂志,2010,17(2):24.
 DAI Xia,ZOU Yan-jun,BU Shuai,et al.Clinical Retrospective Study of Distribution of TCM Syndrome for Elderly Hypertension[J].zhongguo zhongyiyao xinxi zazhi,2010,17(6):24.
[3]汪红兵,张声生,李振华,等.360例腹泻型肠易激综合征主要证候分布与不同因素关系的研究[J].中国中医药信息杂志,2010,17(3):18.
 WANG Hong-bing,ZHANG Sheng-sheng,LI Zhen-hua,et al.Study on Relationship between the Main Symptoms Distribution and Different Factors of 360 Cases of IBS-D[J].zhongguo zhongyiyao xinxi zazhi,2010,17(6):18.
[4]刘敏,赵亚伟,高星亮.慢性胆囊炎中医证候研究[J].中国中医药信息杂志,2010,17(4):22.
 LIU Min,ZHAO Ya-wei,GAO Xing-liang.Study on TCM Syndromes of Chronic Cholecystitis[J].zhongguo zhongyiyao xinxi zazhi,2010,17(6):22.
[5]刘绍能,蔡冬,燕东,等.功能性便秘中医证候分布与焦虑抑郁相关性研究[J].中国中医药信息杂志,2011,18(2):22.[doi:10.3969/j.issn.1005-5304.2011.02.010]
 LIU Shao-neng,Cai Dong,YAN Dong,et al.Correlative Study on Distribution of TCM Syndromes and Anxiety-Depression in Functional Constipation[J].zhongguo zhongyiyao xinxi zazhi,2011,18(6):22.[doi:10.3969/j.issn.1005-5304.2011.02.010]
[6]姜永红,姜之炎,马晶,等.小儿支原体肺炎中医证候与TH细胞相关性研究[J].中国中医药信息杂志,2011,18(2):27.[doi:10.3969/j.issn.1005-5304.2011.02.012]
 JIANG Yong-hong,JIANG Zhi-yan,MA Jing,et al.Study on the Relativity between TCM Syndrome and TH Cells of Mycoplasma Pneumoniae Pneumonia[J].zhongguo zhongyiyao xinxi zazhi,2011,18(6):27.[doi:10.3969/j.issn.1005-5304.2011.02.012]
[7]李晔,李怡.与血脂变化相关的中医证候分析[J].中国中医药信息杂志,2010,17(7):25.
 LI Ye,LI Yi.Analysis on TCM Syndromes Related to Changes of Blood Lipid[J].zhongguo zhongyiyao xinxi zazhi,2010,17(6):25.
[8]施怡,李冬云,陈信义.难治性血小板减少性紫癜中医学四诊信息回顾性调查[J].中国中医药信息杂志,2010,17(7):28.[doi:10.3969/j.issn.1005-5304.2010.07.012]
 SHI Yi,LI Dong-yun,CHEN Xin-yi.Retrospective Clinical Study on TCM Syndrome Features of Refractory Idiopathic Thrombocytopenic Purpura[J].zhongguo zhongyiyao xinxi zazhi,2010,17(6):28.[doi:10.3969/j.issn.1005-5304.2010.07.012]
[9]刘新敏,华强.从现代文献探讨多囊卵巢综合征的中医证候及证候要素分布特点[J].中国中医药信息杂志,2011,18(2):34.[doi:10.3969/j.issn.1005-5304.2011.02.015]
 LIU Xin-min,HUA Qiang.Investigation on Distributed Feature of TCM Syndrome and Syndrome Elements about Polycystic Ovary Syndrome from Modern Literature[J].zhongguo zhongyiyao xinxi zazhi,2011,18(6):34.[doi:10.3969/j.issn.1005-5304.2011.02.015]
[10]白云静,申洪波,姜德训,等.证候诊断因子优化组合的方法研究[J].中国中医药信息杂志,2010,17(10):1.[doi:10.3969/j.issn.1005-5304.2010.10.001]
 [J].zhongguo zhongyiyao xinxi zazhi,2010,17(6):1.[doi:10.3969/j.issn.1005-5304.2010.10.001]
[11]潘志强,方肇勤.中医证候本质研究现状及引入系统生物学技术新趋势[J].中国中医药信息杂志,2009,16(1):104.
 [J].zhongguo zhongyiyao xinxi zazhi,2009,16(6):104.

备注/Memo

基金项目:国家自然科学基金(81673795、81503536、81603578)

更新日期/Last Update:

2020-05-14