CAO Jiangyong,ZHAO Binghua,XU Wenjiang,et al.Clinical Study on Self-made Bingsha Zhitong Tincture as an Adjunct to Opioids for Treatment of Moderate and Severe Cancer Pain[J].zhongguo zhongyiyao xinxi zazhi,2020,27(8):41-45.[doi:10.3969/j.issn.1005-5304.202002037]
自拟冰砂止痛酊外用辅助阿片类药物治疗中重度癌性疼痛临床研究
- Title:
- Clinical Study on Self-made Bingsha Zhitong Tincture as an Adjunct to Opioids for Treatment of Moderate and Severe Cancer Pain
- 文章编号:
- 1005-5304(2020)08-0041-05
- Keywords:
- cancer pain; Bingsha Zhitong Tincture; anxiety; depression; quality of life; clinical study
- 分类号:
- R273
- 文献标志码:
- A
- 摘要:
- 目的 探讨自拟冰砂止痛酊外用辅助阿片类药物治疗癌性疼痛的临床疗效。方法 采用随机数字表法将120例中重度癌性疼痛患者分为对照组和研究组各60例。在常规治疗基础上，研究组予自拟冰砂止痛酊，对照组予安慰剂，均每6 h 1 次，涂擦痛处。2组疗程均14 d。观察2组临床疗效，比较2组疼痛数字评分法（NRS）评分、匹兹堡睡眠质量指数（PSQI）、焦虑自评量表（SAS）评分、抑郁自评量表（SDS）评分、癌症患者生活质量问卷评分，监测2组不良反应。结果 研究组总有效率为90.0%（54/60），对照组为75.0%（45/60），2组比较差异有统计学意义（P＜0.05）。与本组治疗前比较，2组治疗7、14 d NRS、PSQI、SAS、SDS评分明显下降（P＜0.05）；2组治疗同一时点比较，研究组治疗7、14 d NRS、PSQI、SAS、SDS评分明显低于对照组（P＜0.05）。与本组治疗前比较，2组治疗后总体生命质量、躯体功能、角色功能、认知功能、情感功能、社会功能评分明显升高（P＜0.05）；研究组治疗后上述评分明显高于对照组（P＜0.05）。2组不良反应比较差异无统计学意义（P＞0.05）。结论 自拟冰砂止痛酊外用辅助阿片类药物治疗癌性疼痛具有较好的镇痛效果，可改善患者焦虑、抑郁情绪及生活质量。
- Abstract:
- Objective To explore the clinical efficacy of self-made Bingsha Zhitong Tincture as an adjunct to opioids for the treatment of cancer pain. Methods Totally 120 patients with moderate or severe cancer pain were randomly divided into control group and study group according to random number table method, with 60 cases in each group. On the basis of routine treatment, the study group received self-made Bingsha Zhitong Tincture on the sore area every 6 hours, and the control group received placebo. Both groups were given a course of 14 days. Pain numeric rating scales (NRS) scores, Pittsburgh sleep q uality Index (PSQI), anxiety self-rating scale (SAS) scores, depression self-rating scale (SDS) scores, and cancer patients’ quality of life questionnaire score in the two groups were compared. Adverse reactions in both groups were observed. Results The total effective rate in the study group was 90.0% (54/60) and that in the control group was 75.0% (45/60), with statistical significance ( P<0.05). Compared with before treatment, the scores of NRS, PSQI, SAS, and SDS decreased significantly in the two groups on 7 and 14 days (P<0.05); Comparing the two treatment groups at the same time point, the NRS, PSQI, SAS, and SDS scores of the study group were significantly lower than those of the control group on 7 and 14 days of treatment (P<0.05). Compared with before treatment, the overall quality of life, physical function, role function, cognitive function, emotional function, and social function score of the two groups after treatment significantly increased (P<0.05); After treatment, the above scores in the study group were significantly higher than those in the control group (P<0.05). There was no statistical significance in adverse reactions between the two groups (P>0.05). Conclusion Self-made Bingsha Zhitong Tincture as an adjunct to opioids has a good analgesic effect on cancer pain and improves patients’ anxiety, depression and quality of life.
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备注/Memo
基金项目：廊坊市科技支撑计划（2016013138）
更新日期/Last Update:
2020-07-20