[1]杨仁义,刘利娟,康蕾,等.基于网络药理学的活血荣络方对脑梗死血管新生作用机制研究[J].中国中医药信息杂志,2020,27(8):98-105.[doi:10.3969/j.issn.1005-5304.201907340]
 YANG Renyi,LIU Lijuan,KANG Lei,et al.Study on Mechanism of Huoxue Rongluo Prescription in Angiogenesis of Cerebral Infarction Based on Network Pharmacology[J].zhongguo zhongyiyao xinxi zazhi,2020,27(8):98-105.[doi:10.3969/j.issn.1005-5304.201907340]
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基于网络药理学的活血荣络方对脑梗死血管新生作用机制研究

参考文献/References:

[1] GBD 2017 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017:a systematic analysis for the Global Burden of Disease Study 2017[J]. Lancet,2018,392(10159):1859- 1922.

[2] 吴以岭,魏聪,贾振华,等.脉络学说概要及其应用[J].中医杂志, 2014,55(3):181-184.

[3] RU J, LI P, WANG J, et al. TCMSP:a database of systems pharmacology for drug discovery from herbal medicines[J]. J Cheminform,2014,6:13.

[4] MORCOS P N, YU L, BOGMAN K, et al. Absorption, distribution, metabolism and excretion (ADME) of the ALK inhibitor alectinib:results from an absolute bioavailability and mass balance study in healthy subjects[J]. Xenobiotica,2017,47(3):217-229.

[5] TIAN S, LI Y, WANG J, et al. ADME evaluation in drug discovery. 9. Prediction of oral bioavailability in humans based on molecular properties and structural fingerprints[J]. Mol Pharm,2011,8(3):841-851.

[6] TIAN S, WANG J, LI Y, et al. Drug-likeness analysis of traditional Chinese medicines:prediction of drug-likeness using machine learning approaches[J]. Mol Pharm,2012,9(10):2875-2886.

[7] GIBALDI M, LWVY G. Pharmacokinetics in clinical practice. 2. Applications[J]. JAMA,1976,235(18):1987-1992.

[8] KIM S, CHEN J, CHENG T, et al. PubChem 2019 update:improved access to chemical data[J]. Nucleic Acids Res,2019,47(D1):D1102- D1109.

[9] Editorial:ChemSpider - a tool for natural products research[J]. Nat Prod Rep,2015,32(8):1163-1164.

[10] GFELLER D, MICHIELIN O, ZOETE V. Shaping the interaction landscape of bioactive molecules[J]. Bioinformatics,2013, 29(23):3073-3079.

[11] UNIPROT CONSORTIUM T. UniProt:the universal protein knowledgebase[J]. Nucleic Acids Res,2018,46(5):2699.

[12] FISHILEVICH S, NUDEL R, RAPPAPORT N, et al. GeneHancer:genome-wide integration of enhancers and target genes in GeneCards[J]. Database (Oxford),2017.DOI10.1093/database/bax028.

[13] VON MERING C, JENSEN L J, SNEL B, et al. STRING:known and predicted protein-protein associations, integrated and transferred across organisms[J]. Nucleic Acids Res,2005,33 (Database issue):433-437.

[14] SZKLARCZYK D, GABLE A L, LYON D, et al. STRING v11:protein- protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets[J]. Nucleic Acids Res,2019,47(D1):D607-D613.

[15] DENNIS G, SHERMAN B T, HOSACK D A, et al. DAVID:database for annotation, visualization, and integrated discovery[J]. Genome Biol,2003,4(5):P3.

[16] 周德生,陈湘鹏,胡华,等.脑梗死荣气虚滞病机特征之探讨[J].中西医结合心脑血管病杂志,2014,12(12):1560-1561,1576.

[17] 解静,高杉,李琳,等.网络药理学在中药领域中的研究进展与应用策略[J].中草药,2019,50(10):2257-2265.

[18] ERLER J T, LINDING R. Network-based drugs and biomarkers[J]. The Journal of Pathology,2010,220(2):290-296.

[19] LIANG K, YE Y, WANG Y, et al. Formononetin mediates neuroprotection against cerebral ischemia/reperfusion in rats via downregulation of the Bax/Bcl-2 ratio and upregulation PI3K/Akt signaling pathway[J]. J Neurol Sci,2014,344(1/2):100- 104.

[20] LIU C, WU J, XU K, et al. Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway[J]. J Neurochem, 2010,112(6):1500-1512.

[21] 周德生,刘利娟,寇志刚,等.活血荣络片对大脑中动脉缺血模型大鼠脑组织微囊蛋白-1表达的影响[J].河北中医,2016,38(1):80-84,163.

[22] 周德生,刘利娟,寇志刚,等.活血荣络片对大鼠MCAO模型脑组织MVD表达的影响[J].河南中医,2015,35(5):956-959.

[23] ZHOU D, LI M, HU H, et al. Huoxue Rongluo Tablet reduces matrix metalloproteinase-9 expression in infarcted brain tissue[J]. Neural Regen Res,2013,8(34):3216-3224.

[24] 周颖璨,王洪海,周德生,等.活血荣络方对大鼠脑缺血再灌注损伤JAK2、STAT3表达的影响[J].时珍国医国药,2017,28(9):2111-2114.

[25] ZHANG J, YAO C, CHEN J, et al. Hyperforin promotes post-stroke functional recovery through interleukin (IL)-17A-mediated angiogenesis[J]. Brain Res,2016,1646:504-513.

[26] 陈瑶,周德生,胡华.活血荣络方对Aβ25-35损伤神经胶质细胞Wnt5α、Fz5、CaMKⅡ表达的影响[J].中华中医药学刊,2016,34(10):2438-2441.

[27] LIPFERT J, ÖDEMIS V, WAGNER D C, et al. CXCR 4 and CXCR 7 form a functional receptor unit for SDF-1/CXCL 12 in primary rodent microglia[J]. Neuropathol Appl Neurobiol,2013,39(6):667-680.

[28] 刘超,刘敬霞,任非非,等.中医药保护脑缺血再灌注损伤的实验研究进展[J].中国老年学杂志,2016,36(2):481-484.

[29] MA W, WANG S, LIU X, et al. Protective effect of troxerutin and cerebroprotein hydrolysate injection on cerebral ischemia through inhibition of oxidative stress and promotion of angiogenesis in rats[J]. Mol Med Rep,2019,19(4):3148-3158.

[30] Gu N, DONG Y, TIAN Y, et al. Anti-apoptotic and angiogenic effects of intelectin-1 in rat cerebral ischemia[J]. Brain Res Bull,2017,130:27-35.

[31] SHEIKH A M, YANO S, MITAKI S, et al. A mesenchymal stem cell line (B10) increases angiogenesis in a rat MCAO model[J]. Exp Neurol,2019,311:182-193.

[32] LIU H, REN X, MA C. Effect of berberine on angiogenesis and HIF-1α/VEGF signal transduction pathway in rats with cerebral ischemia-reperfusion injury[J]. J Coll Physicians Surg Pak,2018, 28(10):753-757.

[33] XUE L, HUANG J, ZHANG T, et al. PTEN inhibition enhances angiogenesis in an in vitro model of ischemic injury by promoting Akt phosphorylation and subsequent hypoxia inducible factor-1α upregulation[J]. Metab Brain Dis,2018,33(5):1679-1688.

[34] HUANG H, HUANG Q, WANG F, et al. Cerebral ischemia-induced angiogenesis is dependent on tumor necrosis factor receptor 1-mediated upregulation of α5β1 and αVβ3 integrins[J]. J Neuroinflammation,2016,13(1):227.

[35] EL ASSAR M, SANCHEZ-PUELLES J M, ROYO I, et al. FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation[J]. Br J Pharmacol,2015,172(5):1277- 1291.

[36] CHEN J, ZHANG X, LIU X, et al. Ginsenoside Rg1 promotes cerebral angiogenesis via the PI3K/Akt/mTOR signaling pathway in ischemic mice[J]. Eur J Pharmacol,2019,856:172418.

[37] 白剑,迟戈,张俊,等.肌肽对低氧所致大鼠血管内皮细胞损伤的保护作用[J].中国应用生理学杂志,2010,26(1):30-32.

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备注/Memo

基金项目:国家自然科学基金(81874463);湖南省科技计划(2017SK4005);湖南省中医药科研计划(201824、2020045);湖南省财政中医药项目(rsk-010-13[006-09])

更新日期/Last Update:

2020-07-20