[1]王旭杰,张菀桐,王妙然,等.生脉饮“异病同治”糖尿病和心力衰竭的网络药理学作用机制研究[J].中国中医药信息杂志,2021,28(1):19-26.[doi:10.19879/j.cnki.1005-5304.201912494]
 WANG Xujie,ZHANG Wantong,WANG Miaoran,et al.Study on Mechanism of Treating Different Diseases with Same Method of Shengmai Decoction in Treating Diabetes and Heart Failure Based on Network Pharmacology[J].zhongguo zhongyiyao xinxi zazhi,2021,28(1):19-26.[doi:10.19879/j.cnki.1005-5304.201912494]
点击复制

生脉饮“异病同治”糖尿病和心力衰竭的网络药理学作用机制研究

参考文献/References:

[1] PONIKOWSKI P, ANKER S D, ALHABIB K F, et al. Heart failure:preventing disease and death worldwide[J]. ESC Heart Failure, 2014,1(1):4-25.

[2] 陈树.糖尿病与心力衰竭的研究及进展[J].中国医学前沿杂志(电子版),2012,4(3):31-35.

[3] KHAN S S, BUTLER J, GHEORGHIADE M. Management of comorbid diabetes mellitus and worsening heart failure[J]. JAMA,2014, 311(23):2379-2380.

[4] 邓中甲.方剂学[M].北京:中国中医药出版社,2006:157.

[5] 王世华,李新龙,何丽云,等.基于古籍文献的生脉散适应病证可视化分析[J].中医杂志,2019,60(9):745-749.

[6] 王晓宁,施红.复方丹参、玉液汤、生脉散对糖尿病大鼠糖化血清蛋白、游离脂肪酸的作用[J].福建中医学院学报,2006,16(6):37-39.

[7] 邓路娟,闫铭,朱建良.生脉散对Ⅱ型糖尿病大血管损伤大鼠血清sVCM-1与TNF-α的影响[J].河北医药,2008,30(9):1416-1417.

[8] 陈立军,汪宁.生脉注射液对高糖和糖化终末产物诱导的肾小球系膜细胞增殖的影响[J].南京中医药大学学报,2010,26(6):445-446.

[9] 邓元江,梁伟雄,刘卫英,等.生脉胶囊对慢性心力衰竭大鼠心肌细胞凋亡的影响[J].中国中医药信息杂志,2009,16(4):27-29.

[10] 钟耀生.应用生脉注射液对急性心肌梗死后左室容积和功能的影响[J].武汉职工医学院学报,1998,26(4):1-3.

[11] 肖静.生脉液对心血管系统的作用[J].中国中西医结合杂志,1989, 9(11):700.

[12] 毛静远,王恒和,王强,等.生脉注射液对心力衰竭患者内源性洋地黄物质血清水平的影响[J].中国中医急症,2003,12(6):527-528.

[13] RU J L, LI P, WANG Y H, et al. TCMSP:A database of systems pharmacology for drug discovery from herbal medicines[J]. J Cheminform,2014.DOI:10.1186/1758-2946-6-13.

[14] BINDEA G, MLECNIK B, HACKL H, et al. ClueGO:a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks[J]. Bioinformatics,2009,25(8):1091-1093.

[15] 温屯清,阳召军,雷希龄,等.生脉降糖汤治疗2型糖尿病气阴两虚型70例临床观察[J].光明中医,2006,21(1):63-65.

[16] 邓荞.生脉散加味治疗气阴两虚型糖尿病97例[J].光明中医,2014, 29(5):977-978.

[17] ZHOU Q, QIN W Z, LIU S B , et al. Shengmai (a traditional Chinese herbal medicine) for heart failure[J]. Cochrane Database of Systematic Reviews (Online),2014,4(4):CD005052.

[18] ZHAO Z S, ZHAO C Y, ZHANG X H. Advanced glycation end products inhibit glucose-stimulated insulin secretion through nitric oxide-dependent inhibition of cytochrome c oxidase and adenosine triphosphate synthesis[J]. Endocrinology,2009,150(6):2569-2576.

[19] COUGHLAN M T, YAP F Y T, TONG D C K, et al. Advanced glycation end products are direct modulators of β-cell function[J]. Diabetes,2011,60(10):2523-2532.

[20] SAISHO Y, MARUYAMA T, HIROSE H, et al. Relationship between proinsulin-to-insulin ratio and advanced glycation endproducts in Japanese type 2 diabetic subjects[J]. Diabetes Research & Clinical Practice,2007,78(2):182-188.

[21] 农伟虎,许惠琴.糖基化终末产物与糖尿病肾病产生机制的研究进展[J].南京中医药大学学报,2012,28(2):195-197.

[22] 邵亚辉,许顶立.糖基化终极产物对心血管系统的损伤作用及干预措施[J].中国分子心脏病学杂志,2004,4(4):253-256.

[23] PETROVA R, YAMAMOTO Y, MURAKI K, et al. Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes[J]. J Mol Cell Cardiol,2002,34(10):1425-1431.

[24] 周方圆,杨宇峰,石岩.2型糖尿病胰岛素与胰岛素抵抗信号转导通路研究进展[J].辽宁中医药大学学报,2016,18(11):71-73.

[25] 赵娅,张迎,张庆五,等.老年心力衰竭患者与胰岛素抵抗的相关性研究[J].实用糖尿病杂志,2013,9(6):42-44.

[26] 崔萌,孙建平,周丽敏.尿液生物学标记物在早期糖尿病肾病的研究进展[J].中国中西医结合肾病杂志,2016,17(3):263-265.

[27] LI X C, ZHUO J L. Recent updates on the proximal tubule renin- angiotensin system in angiotensinⅡ-dependent hypertension[J]. CurrHypertens Rep,2016,18(8):63.

[28] 熊琴梅,洪葵.心力衰竭分子治疗机制探讨[J].中国医药生物技术, 2011,6(2):127-130.

[29] 贺启莲,格日力,李占强,等.高原适应遗传学缺氧诱导因子通路相关基因及其药理学研究进展[J].药学学报,2019,54(4):611-619.

[30] LEE S H, WOLF P L, ESCUDERO R, et al. Early expression of angiogenesis factors in acute myocardial ischemia and infarction[J]. N Engl J Med,2000,342(9):626-633.

[31] HÖLSCHER M, SCHÄFER K, KRULL S, et al. Unfavourable consequences of chronic cardiac HIF-1α stabilization[J]. Cardiovasc Res,2012,94(1):77-86.

[32] 景丽峰.PI3K/Akt-HIF-1信号系统在糖尿病创面愈合过程中的表达及其意义[D].广州:南方医科大学,2014.

[33] BATHGATE R A, IVELL R, SANBORN B M, et al. International Union of Pharmacology:Recommendations for the nomenclature of receptors for relaxin family peptides[J]. Pharmacol Rev,2006, 58(1):7-31.

[34] TEERLINK J R, COTTER G, DAVISON B A, et al. Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAXAHF):a randomised, placebo-controlled trial[J]. Lancet, 2013,381(9860):29-39.

[35] 戎成振,卢家忠.松弛素治疗心力衰竭的研究进展[J].心脏杂志, 2018,30(3):368-371.

[36] 朱艳艳,潘嘉林,陈灵芝,等.慢性心力衰竭患者血浆H2松弛素的表达[J].温州医科大学学报,2015,45(1):22-25.

[37] BANI D, PINI A, KA-SHENG Y S. Relaxin, insulin and diabetes:An intriguing connection[J]. Current Diabetes Reviews,2012,8(5):329-335.

相似文献/References:

[1]张贵彪,陈启龙,苏式兵?.中药网络药理学研究进展[J].中国中医药信息杂志,2013,20(8):103.[doi:10.3969/j.issn.1005-5304.2013.08.049]
 [J].zhongguo zhongyiyao xinxi zazhi,2013,20(1):103.[doi:10.3969/j.issn.1005-5304.2013.08.049]
[2]于慧卿,孟云辉,李永新,等.四妙勇安汤合生脉饮对缺氧/复氧乳鼠心肌细胞凋亡的影响[J].中国中医药信息杂志,2013,20(12):35.[doi:10.3969/j.issn.1005-5304.2013.12.013]
 YU Hui-qing,MENG Yun-hui,LI Yong-xin,et al.Effect of Simiaoyongan Decoction with Shengmai Decoction on Apoptosis of Hypoxia/ Reoxygenation Neonatal Rat Cardiomyocytes[J].zhongguo zhongyiyao xinxi zazhi,2013,20(1):35.[doi:10.3969/j.issn.1005-5304.2013.12.013]
[3]李从林,王博龙.基于网络药理学的益母草作用机制分析[J].中国中医药信息杂志,2018,25(12):102.[doi:10.3969/j.issn.1005-5304.2018.12.024]
 LI Cong-lin,WANG Bo-long.Analysis on Mechanism of Effects of Leonu ri Herba Based on Network Pharmacology[J].zhongguo zhongyiyao xinxi zazhi,2018,25(1):102.[doi:10.3969/j.issn.1005-5304.2018.12.024]
[4]彭艳红,蒋亦昕,白光,等.胃炎康方对慢性非萎缩性胃炎患者胃泌素相关基因调控通路影响[J].中国中医药信息杂志,2019,26(2):42.[doi:10.3969/j.issn.1005-5304.2019.02.010]
 PENG Yanhong,JIANG Yixin,BAI Guang,et al.Effect of Weiyankang Prescription on Gastrin-related Gene Regulation Pathway of Chronic Non-atrophic Gastritis[J].zhongguo zhongyiyao xinxi zazhi,2019,26(1):42.[doi:10.3969/j.issn.1005-5304.2019.02.010]
[5]严卿莹,叶晔,冯冠,等.基于网络药理学的虎杖治疗结直肠癌作用机制研究[J].中国中医药信息杂志,2019,26(4):96.[doi:10.3969/j.issn.1005-5304.2019.04.020]
 YAN Qingying,YE Ye,FENG Guan,et al.Study on Mechanism of Polygoni Cuspidati Rhizoma et Radix in Treatment of Colorectal Cancer Based on Network Pharmacology[J].zhongguo zhongyiyao xinxi zazhi,2019,26(1):96.[doi:10.3969/j.issn.1005-5304.2019.04.020]
[6]李康宁,王蕾,于佳佳,等.基于网络药理学的补肾益髓胶囊治疗多发性硬化机制研究[J].中国中医药信息杂志,2019,26(5):98.[doi:10.3969/j.issn.1005-5304.2019.05.021]
 LI Kangning,WANG Lei,YU Jiajia,et al.Mechanism Study on Bushen Yisui Capsules for Treatment of Multiple Sclerosis Based on Network Pharmacology[J].zhongguo zhongyiyao xinxi zazhi,2019,26(1):98.[doi:10.3969/j.issn.1005-5304.2019.05.021]
[7]李金霞,指导:曹洪欣.基于复杂网络的温心方治疗冠状动脉狭窄机制研究[J].中国中医药信息杂志,2019,26(6):101.[doi:10.3969/j.issn.1005-5304.2019.06.021]
 LI Jinxia,Instructor: CAO Hongxin.Study on Mechanism of Wenxin Decoction in Treating Coronary Artery Stenosis Based on Complex Network[J].zhongguo zhongyiyao xinxi zazhi,2019,26(1):101.[doi:10.3969/j.issn.1005-5304.2019.06.021]
[8]唐标,唐文静,邓常清.基于网络药理学的黄芪和三七主要有效成分配伍抗缺血性脑损伤作用机制研究[J].中国中医药信息杂志,2019,26(7):109.[doi:10.3969/j.issn.1005-5304.2019.07.024]
 TANG Biao,TANG Wenjing,DENG Changqing.Study on Mechanism of Compatibility of Main Active Components of Astragali Radix and Notoginseng Radix et Rhizoma on Cerebral Ischemic Injury Based on Network Pharmacology[J].zhongguo zhongyiyao xinxi zazhi,2019,26(1):109.[doi:10.3969/j.issn.1005-5304.2019.07.024]
[9]刘云娣,高佳珠,杨智华,等.基于网络药理学的补肾益心片治疗高血压分子机制研究[J].中国中医药信息杂志,2019,26(8):104.[doi:10.3969/j.issn.1005-5304.2019.08.021]
 LIU Yundi,GAO Jiazhu,YANG Zhihua,et al.Study on Molecules Mechanism of Bushen Yixin Tablets for Hypertension Based on Network Pharmacology[J].zhongguo zhongyiyao xinxi zazhi,2019,26(1):104.[doi:10.3969/j.issn.1005-5304.2019.08.021]
[10]王韧,樊启猛,李文姣,等.基于网络药理学的鱼腥草治疗支气管炎作用机制研究[J].中国中医药信息杂志,2019,26(10):91.[doi:10.3969/j.issn.1005-5304.2019.10.020]
 WANG Ren,FAN Qimeng,LI Wenjiao,et al.Study on Mechanism of Houttuyniae Herba for Treatment of Bonchitis Based on Network Pharmacology[J].zhongguo zhongyiyao xinxi zazhi,2019,26(1):91.[doi:10.3969/j.issn.1005-5304.2019.10.020]

备注/Memo

基金项目:国家中医药管理局第三届国医大师传承工作室及全国名中医传承工作室建设项目(2018年)

更新日期/Last Update:

2020-12-18