[1]赵志滨,李李,陈欣燕,等.基于网络药理学的泽泻-白术药对治疗血脂异常作用机制研究[J].中国中医药信息杂志,2021,28(10):37-44.[doi:10.19879/j.cnki.1005-5304.202101456]
 ZHAO Zhibin,LI Li,CHEN Xinyan,et al.Study on Mechanism of Medicinal Pair of Alismatis Rhizoma-Atractylodis Macrocephalae Rhizoma in Treatment of Dyslipidemia Based on Network Pharmacology[J].zhongguo zhongyiyao xinxi zazhi,2021,28(10):37-44.[doi:10.19879/j.cnki.1005-5304.202101456]
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基于网络药理学的泽泻-白术药对治疗血脂异常作用机制研究

参考文献/References:

[1] 诸骏仁,高润霖,赵水平,等.中国成人血脂异常防治指南(2016年修订版)[J].中国循环杂志,2016,31(10):937-953.

[2] 国家卫生和计划生育委员会疾病预防控制局.中国居民营养与慢性病状况报告(2015年)[R].北京:人民卫生出版社,2015.

[3] WEI M G, XIONG P H, ZHANG L, et al. Perilla oil and exercise decrease expressions of tumor necrosis factor-α, plasminogen activator inhibitor-1 and highly sensitive C-reactive protein in patients with hyperlipidemia[J]. Journal of Traditional Chinese Medicine,2013,33(2):170-175.

[4] 李浩,胡有志,鲁晓彬,等.芪丹调脂胶囊治疗血脂异常临床观察[J].湖北中医杂志,2012,34(4):18-19.

[5] 吴同启.从脾肝论治高脂血症60例[J].陕西中医,2004,25(2):133- 134.

[6] 吕少锋,曹克强,王培杨.泽泻汤加味治疗高脂血症120例临床观察[J].中医药临床杂志,2005,17(5):454-455.

[7] RU J L, LI P, WANG J N, et al. TCMSP:a database of systems pharmacology for drug discovery from herbal medicines[J]. J Cheminform,2014,6:13.

[8] ANDREA F, DAMIAN S, SUNE F, et al. STRING v9.1:protein-protein interaction networks, with increased coverage andintegration[J]. Nucleic Acids Res,2013,41(Database issue):D808-D815.

[9] HUANG D W, SHERMAN B T, LEMPICKI R A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources[J]. Nature Protoc,2009,4(1):44-57.

[10] 张慧娟,龚苏晓,许浚,等.泽泻药材的研究进展及其质量标志物的预测分析[J].中草药,2019,50(19):4741-4751.

[11] 刘珊珊,郭杰,李宗艾,等.泽泻化学成分及药理作用研究进展[J].中国中药杂志,2020,45(7):1578-1595.

[12] 姚兆敏,陈卫东,仰忠华,等.白术研究进展及其质量标志物(Q-marker)的预测分析[J].中草药,2019,50(19):4796-4807.

[13] 顾思浩,孔维崧,张彤,等.白术的化学成分与药理作用及复方临床应用进展[J].中华中医药学刊,2020,38(1):69-73.

[14] 尹湘君,何庆勇,王阶,等.近40年血脂异常中医证候动态演变规律的研究[J].中华中医药杂志,2018,33(4):1523-1526.

[15] 韩雪,张睦清,王茜,等.泽泻汤对高脂血症大鼠LXRα和ABCA1表达的影响[J].中华中医药学刊,2017,35(12):3107-3109.

[16] 龚树生,张建军,曹广智,等.泽泻的历史及生物活性成分研究进展[J].山西中医学院学报,2000,1(1):28-30.

[17] 许文,罗奋熔,赵万里,等.泽泻降糖活性提取物化学成分研究[J].中草药,2014,45(22):3238-3245.

[18] 黄珍,刘咏松.泽泻降血脂药理作用及物质基础研究进展[J].山西中医学院学报,2008,9(5):55-56.

[19] NAKAJIMA Y, SATOH Y, KATSUMATA M, et al. Terpenoids of Alisma orientale rhizome and the crude drug Alismatis Rhizoma[J]. Phytochemisty,1994,36(1):119-127.

[20] 施凤飞,魏伟,汪玉成,等.24-乙酰泽泻醇A对氧化型低密度脂蛋白诱导巨噬细胞脂代谢因子ABCA1?/span>CD36及炎症因子CD147?/span>MMP-9的影响[J].中国动脉硬化杂志,2016,24(1):7-12.

[21] PRABHAKAR P, REETA K H, MAULIK S K, et al. α-Amyrin attenuates high fructose diet-induced metabolic syndrome in rats[J]. Appl Physiol Nutr Metab,2017,42(1):23-32.

[22] VAN RAALTE D H, LI M, PRITCHARD P H, et al. Peroxisome proliferator-activated receptor (PPAR)-alpha:a pharmacological target with a promising future[J]. Pharm Res,2004,21(9):1531- 1538.

[23] HAN X, WANG T, ZHANG J, et al. Apolipoprotein CⅢ regulates lipoprotein-associated phospholipase A2 expression via the MAPK and NFκB pathways[J]. Biol Open,2015,4(5):661-665.

[24] FERNANDEZ M L, VEGA-LÓPEZ S. Efficacy and safety of sitosterol in the management of blood cholesterol levels[J]. Cardiovasc Drug Rev,2005,23(1):57-70.

[25] SONG M Y, JUNG H W, KANG S Y, et al. Atractylenolide Ⅲ enhances energy metabolism by increasing the SIRT-1 and PGC1α expression with AMPK phosphorylation in C2C12 mouse skeletal muscle cells[J]. Biol Pharm Bull,2017,40(3):339-344.

[26] 汪雯.白术内酯Ⅰ下调TLR4介导的MyD88+人卵巢癌细胞VEGF表达的研究[D].成都:成都中医药大学,2011.

[27] FATIMA L A, CAMPELLO R S, SANTOS R D S, et al. Estrogen receptor 1 (ESR1) regulates VEGFA in adipose tissue[J]. Sci Rep,2017,7(1):16716.

[28] CHOUNG S, KIM J M, JOUNG K H, et al. Epidermal growth factor receptor inhibition attenuates non-alcoholic fatty liver disease in diet-induced obese mice[J]. PLoS One,2019,14(2):e0210828.

[29] WANG L, HUANG Z, HUANG W, et al. Inhibition of epidermal growth factor receptor attenuates atherosclerosis via decreasing inflammation and oxidative stress[J]. Sci Rep,2017,8:45917.

[30] ZHANG Q, LENARDO M J, BALTIMORE D. 30 years of NF-κB:a blossoming of relevance to human pathobiology[J]. Cell,2017, 168(1/2):37-57.

[31] 谢治深,黄小虹,袁永,等.泽泻抑制脂多糖诱导的RAW264.7炎症及作用机制[J].时珍国医国药,2020,31(7):1586-1590.

[32] 陈琴华,余飞,王红梅,等.白术内酯Ⅰ?/span>Ⅱ?/span>Ⅲ对炎性巨噬细胞细胞因子表达的影响[J].中国药师,2017,20(12):2112-2116.

[33] LIU J, WANG Y, LIN L. Small molecules for fat combustion:targeting obesity[J]. Acta Pharm Sin B,2019,9(2):220-236.

[34] 吴凝,刘石密,万玲,等.茵陈五苓散通过p38?/span>p42/44MAPK通路调控高脂血症大鼠LDL-C的研究[J].中华中医药杂志,2015,30(10):3639- 3643.

[35] WU Y R, SHI X Y, MA C Y, et al. Liraglutide improves lipid metabolism by enhancing cholesterol efflux associated with ABCA1 and ERK1/2 pathway[J]. Cardiovasc Diabetol,2019,18(1):146.

[36] YOSHIDA I, ITO C, MATSUDA S, et al. Alisol B, a triterpene from Alismatis rhizoma (dried rhizome of Alisma orientale), inhibits melanin production in murine B16 melanoma cells[J]. Biosci Biotechnol Biochem,2017,81(3):534-540.

[37] 娄海霞.泽泻醇A-24-醋酸酯促进脂肪细胞脂肪分解并抑制肝细胞脂肪变性的作用机制研究[D].上海:华东师范大学,2018.

[38] SAHU A. Intracellular leptin-signaling pathways in hypothalamic neurons:the emerging role of phosphatidylinositol-3 kinase-phosphodiesterase-3B-cAMP pathway[J]. Neuroendocrinology, 2011,93(4):201-210.

[39] CHEN Q, CHAO Y, ZHANG W, et al. Activation of estrogen receptor α (ERα) is required for Alisol B23-acetate to prevent post-menopausal atherosclerosis and reduced lipid accumulation[J]. Life Sci,2020,258:118030.

[40] 孙伟桂,叶章群,王宏志,等.白术挥发油对LNCaP与DU145细胞表达性激素和PSA等指标的影响及意义[J].中华泌尿外科杂志,2012, 33(12):947-950.

[41] GASPAR J M, MENDES N F, CORRÊA-DA-SILVA F, et al. Downregulation of HIF complex in the hypothalamus exacerbates diet-induced obesity[J]. Brain Behav Immun,2018,73:550-561.

[42] WU L, ZHANG L, LI B, et al. AMP-activated protein kinase (AMPK) regulates energy metabolism through modulating thermogenesis in adipose tissue[J]. Front Physiol,2018,9:122.

[43] HO C, GAO Y, ZHENG D, et al. Alisol A attenuates high-fat- diet-induced obesity and metabolic disorders via the AMPK/ACC/ SREBP-1c pathway[J]. J Cell Mol Med,2019,23:5108-5118.

[44] CHAO C L, HUANG H C, LIN H C, et al. Sesquiterpenes from BaiZhu stimulate glucose uptake by activating AMPK and PI3K[J]. Am J Chin Med,2016,44(5):963-979.

[45] CAMANDOLA S, MATTSON M P. Toll-like receptor 4 mediates fat, sugar, and umami taste preference and food intake and body weight regulation[J]. Obesity (Silver Spring),2017,25(7):1237-1245.

[46] OKLA M, ZAHER W, ALFAYEZ M, et al. Inhibitory effects of toll-like receptor 4, NLRP3 inflammasome, and interleukin-1β on white adipocyte browning[J]. Inflammation,2018,41(2):626-642.

[47] LONG F, LIN H, ZHANG X, et al. Atractylenolide-I suppresses tumorigenesis of breast cancer by inhibiting toll-like receptor 4-mediated nuclear factor-κB signaling pathway[J]. Front Pharmacol,2020,11:598939.

[48] 郭雨雅,孙晓琦,方晶,等.加味泽泻汤对NAFLD大鼠肝脏炎症信号通路相关蛋白表达的影响[J].中国实验方剂学杂志,2017,23(5):90-94.

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备注/Memo

基金项目:省部共建中医湿证国家重点实验室专项(SZ2020ZZ11)

更新日期/Last Update:

2021-09-22